Dimers Aren’t Forever: CD80 Breaks up with PD-L1
نویسندگان
چکیده
منابع مشابه
PD-L1 interacts with CD80 to regulate graft-versus-leukemia activity of donor CD8+ T cells.
Programmed death ligand-1 (PD-L1) interacts with programmed death-1 (PD-1) and the immunostimulatory molecule CD80 and functions as a checkpoint to regulate immune responses. The interaction of PD-L1 with CD80 alone has been shown to exacerbate the severity of graft-versus-host disease (GVHD), whereas costimulation of CD80 and PD-1 ameliorates GVHD. Here we have demonstrated that temporary depl...
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ژورنال
عنوان ژورنال: Immunity
سال: 2019
ISSN: 1074-7613
DOI: 10.1016/j.immuni.2019.11.011